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John Wayles Eppes (April 1772 – September 13, 1823) was an American lawyer and politician. He represented Virginia in the U.S. House of Representatives from 1803 to 1811 and again from 1813 to 1815. He also served in the U.S. Senate (1817–1819). His positions in Congress occurred after he served in the Virginia House of Delegates representing Chesterfield County (1801–1803).

Mary Jefferson Eppes (August 1, 1778 – April 17, 1804), known as Polly in childhood and Maria as an adult, was the younger of Thomas Jefferson's two daughters with his wife who survived beyond the age of 3. She married a first cousin, John Wayles Eppes, and had three children with him. Only their son Francis W. Eppes survived childhood. Maria died months after childbirth.